If you're using a GLP-1 medication like Ozempic®, Wegovy®, or Mounjaro®, you may have noticed unexpected changes in your skin like thinner texture, more visible wrinkles, or a loss of firmness. This is what Dr. Julius Few has identified as GLP Skin™ and GLP Face™, terms that describe the specific skin aging patterns seen in patients using GLP-1 receptor agonists.
To address this problem head-on, Dr. Few and his research team developed DermaReverse, a proprietary serum specifically formulated to help restore the skin in GLP-1 users. Backed by peer-reviewed clinical data published in the Aesthetic Surgery Journal Open Forum, DermaReverse uses state-of-the-art active ingredients to counteract the effects of GLP-1s on the skin.
Let’s take a closer look at the science behind the formula.
H2OA — A Bioavailable Retinoic Acid Derivative
At the heart of DermaReverse is the H2OA Complex, a proprietary retinoic acid derivative designed to be highly bioavailable with minimal irritation. Unlike traditional retinoids, which can cause redness or peeling, H2OA delivers a novel form of retinoic acid in a stabilized, skin-compatible form.
Why it matters for GLP-1 users:
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In our most recent published study, we reference medical literature that describes how GLP-1 drugs may suppress keratinocyte proliferation, which may contribute to epidermal thinning and impaired barrier function.
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Retinoids are known to do the opposite: they can stimulate keratinocyte growth, thicken the epidermis, and restore the skin’s natural regenerative cycles.
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They also can help protect collagen and elastin from degradation — a critical need for patients noticing reduced skin elasticity while on GLP-1 therapy.
As our peer-reviewed and published clinical study notes, this complex was specifically shown to improve multiple different skin quality measures in GLP-1 treated patients, including skin hydration, redness, surface texture, wrinkles, pore size, and elasticity*.
HP4 Peptide Complex — Palmitoyl Oligopeptide + Palmitoyl Tetrapeptide
This peptide blend is what we call HP4, and it plays a critical role in helping to restore skin texture and elasticity.
Why it matters for GLP-1 users:
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These peptides are the building blocks of collagen and elastin — both of which appear to degrade more rapidly in GLP-1 affected skin.
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Clinical studies show these peptides reduce the appearance of fine lines and wrinkles, improve skin tone, and can enhance elasticity.
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In the DermaReverse study, improvements to firmness, hydration, and smoothness were seen as early as 3 weeks in*.
*In a 6 week clinical study published in Aesthetic Surgery Journal Open Forum of DermaReverse™ being applied twice daily
The HP4 complex complements H2OA by signaling your skin to rebuild what GLP-1 therapy may be breaking down.
Aloe Leaf Juice
Aloe isn’t just soothing — it’s biologically active in ways that benefit compromised skin barriers.
Why it matters for GLP-1 users:
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Aloe contains polysaccharides that may enhance wound healing and moisture retention.
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It’s anti-inflammatory, which can help calm skin that may be sensitized by retinoids or peptides.
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It supports skin hydration and barrier repair, both of which may be weakened by GLP-1 therapy.
Sodium Hyaluronate
A form of hyaluronic acid that penetrates deeply and binds water at the cellular level.
Why it matters for GLP-1 users:
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Epidermal thinning can make skin more prone to dehydration.
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Sodium hyaluronate helps restore plumpness, minimize visible pores, and improve texture.
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In our clinical trial, hydration was one of the most rapidly improved categories.
Clinically Tested, Purpose-Built
DermaReverse™ is not just another anti-aging serum. It was specifically developed to meet the needs of GLP-1 users, and it’s been clinically-demonstrated in a peer-reviewed, medical-journal-published study to significantly benefit skin in GLP-1 patients.
If you’re seeing signs of GLP Skin™, don’t wait. Start reversing them with science on your side.