DermaReverse™: Clinically-Proven Skincare for GLP-1 Users
Morning & Night Treatment
The First Clinically-Proven Solution for GLP Face™ & GLP-1 Skincare Concerns
DermaReverse™ is a revolutionary skincare treatment specifically formulated by board-certified plastic surgeon Dr. Julius Few to address the unique skin concerns experienced by GLP-1 medication users. As the first skincare solution for GLP-1 users to be supported by a published, peer-reviewed clinical study, DermaReverse™ targets visible sagging, skin thinning, hyperpigmentation, and texture concerns that commonly occur during GLP-1 weight loss treatment.
Clinically-Proven Results for GLP-1 Users
In our peer-reviewed, double-blind, placebo-controlled clinical study published in the Aesthetic Surgery Journal Open Forum, DermaReverse™ delivered remarkable results for GLP-1 users*:
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100% of participants experienced improved wrinkle appearance
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100% of participants showed reduced surface roughness
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100% of participants had visible reduction in redness
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100% of participants reported improved skin hydration
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100% of participants confirmed DermaReverse™ was gentle enough for daily use
Advanced Anti-Aging Formula for GLP-1 Medication Side Effects
DermaReverse™ combines Dr. Few's surgical expertise with cutting-edge skincare technology to address the specific skin challenges faced by those on GLP-1 medications like Ozempic, Wegovy, and Mounjaro. This specialized treatment targets:
- Facial volume loss and sagging
- Increased skin thinning and fragility
- Fine lines and wrinkles
- Hyperpigmentation and uneven skin tone
- Dryness and dehydration
Proprietary Complexes for Maximum GLP Face™ Benefits
DermaReverse™ is powered by two exclusive, proprietary technology complexes developed by Dr. Few:
H2OA Complex
A bioavailable retinoic acid derivative complex designed for fast absorption into the skin, delivering quick effectiveness without irritation—ideal for the thinning skin common with GLP-1 use.
HP4 Peptide Complex
A synergistic blend of complementary peptides that work together to stimulate collagen and elastin production, reduce the appearance of fine lines and wrinkles, and minimize irritation—perfect for addressing GLP Face™ concerns.
Additional Key Ingredients
- Sodium Hyaluronate: A derivative of hyaluronic acid that helps improve skin firmness, smooth fine lines, and deeply hydrate skin that's become dry from GLP-1 treatments
- Aloe Leaf Juice: Soothing botanical that reduces skin inflammation and redness
- Chamomile: Skin-calming botanical with protective antioxidant benefits
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Calendula: Rich in natural antioxidants that protect skin from free-radical damage while hydrating, firming, and soothing stressed skin
How to Use DermaReverse™ for GLP-1 Skin Concerns
- After cleansing, apply 2-3 drops to clean fingertips
- Gently massage a thin layer into the face, neck, and décolletage, avoiding the delicate eye area
- Can be used morning and night for maximum benefits
- Always apply SPF 30+ sunscreen when using during the day
- Follow with an appropriate moisturizer for your skin type
Who Can Benefit from DermaReverse™?
DermaReverse™ is specifically designed for:
- Current GLP-1 medication users experiencing skin changes
- Former GLP-1 users looking to restore skin quality
- Anyone experiencing premature skin thinning or aging
- Those seeking a gentle yet effective alternative to traditional retinol
*In a 6-week, double-blind, placebo-controlled clinical trial published in the Aesthetic Surgery Journal Open Forum. Results verified by independent board-certified plastic surgeons, and third party independent medical journal reviewers.
IMPORTANT NOTE: if you are pregnant or breastfeeding, refrain from using this product. Consult a physician prior to using any topical product containing retinoic acid / Vitamin A derivatives.

How to use
It’s so easy to apply
- Step 1 After cleansing, apply 2-3 drops to clean fingertips.
- Step 2 Gently massage a thin layer of the product into the face, neck, and décolletage nightly before bed, careful to avoid the delicate area directly around the eyes.
- Step 3 DermaReverse™ can be used morning and night.
- Step 4 Warning: Always apply an SPF 30+ sunscreen when using during the day.
- Step 5 At night and during the day, follow application of DermaReverse™ with the appropriate moisturizer for your skin type.
Key Ingredients

H2OA™
A bioavailable retinoic acid derivative complex designed for fast absorption into the skin, and quick effectiveness without irritation

HP4™ Peptide Complex
A blend of complementary peptides work together to help stimulate collagen and elastin production, reduce the appearance of fine lines & wrinkles, and reduce irritation.

Sodium Hyaluronate
Derivative of hyaluronic acid that helps improve skin firmness, smooth fine lines, and hydrate the skin

Aloe Leaf Juice
Soothing botanical that reduces skin inflammation and redness

Chamomile
Skin soothing botanical ingredient with skin-protective antioxidant benefits

Calendula
a flower rich in natural antioxidants that protects the skin from free-radical damage, whilst also helping to hydrate, firm and soothe stressed skin
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FAQs
Find answers to commonly asked questions about our product, its use, and expected results.
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In Dr. Few's clinical practice, the volume of patients on GLP-1 therapy presenting with visible changes to skin quality became impossible to ignore. That’s when he began referring to the changes in their skin as 'GLP Face' and 'GLP Skin'—a new pattern that demanded attention.
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Yes, DermaReverse™ has been clinically tested for 2x per day use, both morning and night. If using during the day, always apply a broad spectrum mineral sunscreen of SPF 30 or higher.
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No, this product is specifically designed for people who are on or have been on GLP-1s and not just people with weight-loss associated skin change. DermaReverse™ is designed to address the changes observed in GLP-1 users. However, it is also suitable for those experiencing premature thinning of the skin.
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DermaReverse™ contains a proprietary, patent-pending ingredient complex called the H2OA™ Complex. This complex was designed by Dr. Few to deliver a bioavailable form of retinoic acid that can be used twice daily (morning and night) even on skin that is sensitive, experiencing a thinning appearance, or generally sensitive to other forms of Vitamin A, like retinol.
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If used both morning and night on the face, neck, and décolletage areas, one 30mL bottle of DermaReverse™ should last about 30 days.
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We suggest using DermaReverse™ without any other retinol for 6 weeks (per our study protocol) before adding another retinol to your routine. After 6 weeks, if well-tolerated, you can layer it underneath the Clean Retinol from Dr. Few Skincare.
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DermaReverse™ can be started at any time, whether you are on a GLP-1 or not. In our clinical trial, every patient was already using GLP-1 for as little as 6 months, to as long as over 1 year. It is recommended to start using DermaReverse™ before or when you start GLP-1 treatment; but, based on our clinical trial, it's never too late to start.


